Exclusive: T.R. Knight negotiating 'Grey's Anatomy' exit  —  The revolving door at Grey's Anatomy has taken another shocking spin.  —  Multiple sources confirm that T.R. Knight has asked to be released from his contract, a request that both ABC and Grey's show-runner Shonda Rhimes appear poised to grant.

Ruffalo Dies  —  Scott Ruffalo, the brother of actor Mark Ruffalo, died last night after suffering a gunshot wound last week.  —  Brian Scofield and Shaha Mishaal Adham turned themselves in to the Bev Hills PD yesterday.  Adham was named a “suspect” and Scofield was named a"person of interest" in the shooting.

Jennifer Aniston exclusive: Friends star talks for the first time about John Mayer  —  She may have had her heart shredded by the world's sexiest man but Jennifer Aniston keeps coming back for more.  —  And this time the actress - who loved and lost Hollywood heartthrob Brad Pitt - hasn't just fallen head over heels again.

LA PAPER TRAIL  —  MARIAH Carey's wish may finally be coming true.  Spies in LA saw the songbird (above) coming out of a well-known ob/gyn's office on North Crescent Boulevard, “clutching what looked like a sonogram and being greeted by her entourage with cheers.  She was ebullient.”

Tom Cruise Tells Spencer Pratt He Made Wedding Mistake  —  The Hills - MTV Shows  —  In a pre-taped interview on Monday's i>Hills after-show, Tom Cruise was asked what advice he had for Spencer Pratt, who famously eloped with Heidi Montag Nov. 24.  —  Cruise said that Pratt …

Fantasia — Foreclosure's Just a Fantasy!  —  Fantasia Barrino says reports she's about to lose a house are hogwash.  —  Reports say the “AI” winner is about to lose one of her homes in Charlotte, NC: She bought the 6-bed, 6,000-sq. ft. mansion back in 2007 for $1.3 mil (not a misprint) but couldn't keep up on payments.

Britney's Dancers Getting Drug Tested  —  Who knew that the first thing you would hear after being hired to dance for Britney Spears would be, “Fill this, please.”  —  A source tells E! News that, in an effort to keep the on-track pop star free from negative influences …

Oprah Winfrey Admits to Tipping the Scales at 200 Lbs.  —  Oprah Winfrey Dec. 5  —  Having packed 40 pounds onto her former 160-pound self, Oprah Winfrey is declaring, “I'm mad at myself” because she's “fallen off the wagon.”  —  As the media mogul, 54, writes in the January issue …

Anne Hathaway's wedding wish  —  Anne Hathaway wants to get married.  —  The ‘Bride Wars’ star - who split from long-term boyfriend Raffaello Follieri earlier this year - hopes to settle down one day but admits her previous experiences have left her wary of commitment.

WHERE IS LENO GOING?  TO PRIME TIME, ON NBC  —  NBC will keep Jay Leno five nights a week, but in prime time, competing not with David Letterman, but with shows like “CSI: Miami.”  —  The network will announce Tuesday that Mr. Leno's new show will appear at 10 o'clock each weeknight in a format similar to …

Lost's Josh Holloway to Be a Dad  —  Holloway and wife Yessica  —  Lost hunk Josh Holloway is going to be a daddy.  —  The actor and his wife, Yessica, are expecting their first child, TV Guide reports.  —  The baby is due next year, the 39-year-old actor tells the magazine.